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Against The Grain — Dedicated GF gluten-free restaurant in Mesa, AZ

Against The Grain

🌿 Bakery

124 West Main Street, Mesa, AZDowntown Mesa

Dedicated GF

Celiac family-owned cafe, bakery, and GF grocery on Main Street in Mesa, serving breakfast through dinner seven days a week

We last checked this spot on May 29, 2026 · Sansglu Editorial methodology

The Sansglu take

The place

A cafe, bakery, and small gluten-free grocery on Main Street in downtown Mesa, family-owned and started as, in the owners' words, a labor of love to the celiac community. It keeps full-day hours, 8am to 8pm Monday through Saturday and 9am to 4pm Sunday, which makes it the rare dedicated spot you can hit for dinner.

The gluten-free setup

The entire operation is gluten-free, run by a family that lives gluten-free themselves. Even the beer fridge holds only gluten-free bottles; the shop describes its GF beer selection as Arizona's largest, including Ghostfish.

What to order

The owners describe the menu as one of the largest gluten-free lineups in the country, running from breakfast plates through dinner comfort food, with a bakery case and grocery shelves for take-home. Ask what came out of the oven that day.

The move

Come at dinner. Almost no dedicated gluten-free kitchen in the Valley serves past mid-afternoon, and this one runs to 8pm most nights with a gluten-free beer in reach.

Sansglu Editorial · Updated May 29, 2026

Gluten-free setup

Current facility and preparation details supported by our research.

  • Dedicated facility
  • Trained staff

Gluten-free options

Bread/BunsFriesCinnamon RollsCookies

Featured in Sansglu guides

Gluten-free dishGluten-free pastryGluten-free bread
The Sansglu app showing a map of gluten-free restaurants with a 100 safety score for a dedicated gluten-free spot
See the safety scoreDedicated GF only

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Evidence reviewed by Sansglu · sansglu.com